120 Jobs für Qiagen in Deutschland
Lead Scientist - Molecular Biology (Remote)
Gestern
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Senior Research Scientist - Molecular Biology
Gestern
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Hauptaufgaben und Verantwortlichkeiten:
- Entwicklung, Optimierung und Durchführung komplexer molekularbiologischer Experimente (z.B. PCR, qPCR, Western Blotting, Genomeditierung, Zellkultur).
- Design und Durchführung von Studien zur Validierung von Targets und zur Untersuchung von Krankheitsmechanismen.
- Analyse und Interpretation von experimentellen Daten, Erstellung detaillierter Berichte und Präsentationen.
- Betreuung von Junior-Wissenschaftlern und technischen Assistenten, Anleitung bei experimentellen Designs und Problemlösungen.
- Kontinuierliche Überwachung der wissenschaftlichen Literatur und Identifizierung neuer Technologien und Methoden.
- Zusammenarbeit mit internen und externen Partnern zur Weiterentwicklung von Projekten.
- Vorbereitung von Manuskripten für die Publikation in hochrangigen Fachzeitschriften.
- Budgetplanung und Ressourcenmanagement für zugewiesene Forschungsprojekte.
- Promotion (Ph.D.) in Molekularbiologie, Biochemie, Genetik oder einem verwandten Fachgebiet.
- Nachgewiesene Erfolgsbilanz in der wissenschaftlichen Forschung, belegt durch Publikationen.
- Mindestens 5 Jahre post-doktorale Erfahrung in der akademischen oder industriellen Forschung.
- Umfassende Kenntnisse und praktische Erfahrung in einer breiten Palette molekularbiologischer Techniken.
- Fortgeschrittene Datenanalysefähigkeiten und Erfahrung mit relevanten Softwarepaketen (z.B. GraphPad Prism, R).
- Exzellente schriftliche und mündliche Kommunikationsfähigkeiten in Deutsch und Englisch.
- Fähigkeit, selbstständig zu arbeiten, Prioritäten zu setzen und Projekte erfolgreich abzuschließen.
- Starke Führungskompetenzen und Erfahrung in der Betreuung von Mitarbeitern.
Postdoc - Molecular Biology (m/f/d)
Heute
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versity (HHU) Düsseldorf, is an interdisciplinary research institute that integrates basic and clinical sciences to improve the prevention, diagnosis, and therapy of diabetes mellitus and its complications.
The Junior Research Group Crosstalk (headed by Dr. Melanie Mittenbühler) at the Institute for Clinical Biochemistry and Pathobiochemistry focuses on how inter-tissue communication impacts energy balance and metabolic health. We are currently seeking a talented and highly motivated
Postdoctoral Researcher (Ph.D./Dr. rer. nat., m/f/div., E13 TV-L, 100%)
to join our team. Our research focuses on secreted proteins from adipose and skeletal muscle tissues (adipokines/myokines) and their roles in whole-body metabolism and metabolic disorders. This specific project centers on exercise-induced myokines and their potential to mitigate the metabolic consequences of physical inactivity. The successful candidate will explore the molecular functions of three novel myokines as potential therapeutic targets for obesity and diabetes. The aims of the project are to:
- Assess how these novel myokines affect fat and muscle cell function. li>Uncover the molecular mechanisms by which they influence metabolism.
- Test their therapeutic potential in mouse models.
- Ph.D. or Dr. rer. nat. in molecular biology, biochemistry, physiology, or a related discipline.
- Demonstrated experience in working with mouse models and molecular biology techniques.
- Strong background in metabolism, cell biology, or proteomics.
- Experience with large-scale OMICS data analysis is highly advantageous.
- Ability to work independently and as part of a multidisciplinary team.
- Excellent communication skills in English, both in writing and verbally.
Initially, the position is to be awarded for 2 years starting from 01.01.2026 . An extension of the contract period is envisaged. The employment contract is governed by TV-L in its current version for North Rhine-Westphalia, including the special regulations regarding the scientific area. The salary is based on qualification and experience, according to TV-L.
Females are especially encouraged to apply, and in the case of equal qualification, handicapped per-
sons will be given preference. The German Diabetes Center is committed to family-friendly working
conditions and equal gender policy. Since May 2011, the DDZ is a “Career and Family” audit-acknowledged center. The provisions of § 7 no. 1 of the Act on Part-Time Work and Fixed-Term Employment are taken into account.
PhD - Molecular Biology (m/f/d)
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DNA Polymerase theta (Polθ, encoded by the polq gene) is a predominant mediator of Polθ-mediated end joining (TMEJ) in most eukaryotes (Ramsden et al., Nat Rev Mol Cell Biol 23, 125-140 (2022)). While initially considered a backup pathway, recent studies suggest that TMEJ is a primary repair pathway in specific contexts, including replication stress, DNA damage in cancers cells, and immunoglobulin class-switch recombination (CSR) (Ceccaldi et al., Nature 518, 258-262 (2015); Roerink et al., Genome Res 24, 954-962 (2014); Yan et al., Nature 449, 478-482 (2023)). Intriguingly, many of these conditions are also associated with R-loop accumulation, raising the possibility that Polθ may play a direct role in repairing R-loop-induced damage.
This study, conducted in Caenorhabditis elegans (C. elegans ), will provide fundamental insights into how R-loops influence DNA repair pathway choice and contribute to genome instability. Our findings may also provide novel therapeutic strategies targeting R-loop-associated malignancies.
See also
For a more detailed description of the project including relevant literature, see:
>
This PhD position is part of 4R Research Training Group (GRK2859) “R-loop Regulation in Robustness and Resilience (4R)” ( ), funded by the German Research Foundation (DFG). 4R investigates how R-loops regulate biological processes across scales, from molecules to organisms. At the same time the mechanistic regulation of R-loops themselves is studied. As one of a cohort of 12 4R PhD positions, you will be part of a vibrant interdisciplinary research and training environment with specialized seminar series and tech talks and training courses that develop both scientific and complementary skills.
As a 4R-RTG PhD student, you will be integrated into the International PhD Programme (IPP; ), which is organized by IMB ( ). The IPP offers an exciting, interdisciplinary and lively international community of more than 200 PhD students from over 40 different countries. You will receive a broad range of support including supervision, training and career development opportunities.
- Masters degree or equivalent in a relevant area li>Good experience in molecular biology
- Good communication skills and good team spirit
- Ability to solve problems independently
- Fluent in English (spoken and written)
- Competitive salary and favourable pension scheme
- Advanced training opportunities
- Flexible working hours
- Employee events
- Job Ticket
- Starting Date : as soon as possible
- Duration : the position is initially funded until 30 June 2028; with a possibility of extension
- Deadline : 31 August 2025
- International applicants: we will assist you through the visa process, and also with your application for a residence/work permit after your arrival in Mainz.
PhD - Molecular Biology (m/f/d)
Heute
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Enhancers also produce enhancer RNAs (eRNAs). While proteins have been extensively studied in transcriptional condensate formation, the role of RNAs has received less attention. However, previous studies suggest that short RNAs like eRNAs can trigger phase separation of proteins in transcriptional condensates, and transcription factors can interact directly with RNAs. The presence of eRNAs at enhancer sites, often forming R-loop structures, may be more important than the specific eRNA molecule itself. This leads to the hypothesis that eRNAs play a crucial role in the formation and function of transcriptional condensates , with their impact on transcriptional condensate formation remaining largely unexplored.
Join our dynamic research group at IMB and contribute to the exciting field of gene regulation. We are seeking a motivated PhD student to contribute to our investigations of how transcriptional condensates form and regulate gene expression. In this project, you will focus on the role of eRNAs in condensate formation by exploring different RNA association modes. By combining classic phase separation assays and single molecule reconstitution, you will address the following questions:
- How does the eRNA association mode impact transcription factor condensation in solution? li>How does the eRNA association mode affect the formation of condensates on single molecules of DNA?
- How does the eRNA association mode influence DNA:DNA interaction?
See also
For a more detailed description of the project including relevant literature, see:
This PhD position is part of 4R Research Training Group (GRK2859) “R-loop Regulation in Robustness and Resilience (4R)” ( ), funded by the German Research Foundation (DFG). 4R investigates how R-loops regulate biological processes across scales, from molecules to organisms. At the same time the mechanistic regulation of R-loops themselves is studied. As one of a cohort of 12 4R PhD positions, you will be part of a vibrant interdisciplinary research and training environment with specialized seminar series and tech talks and training courses that develop both scientific and complementary skills.
As a 4R-RTG PhD student, you will be integrated into the International PhD Programme (IPP; ), which is organized by IMB ( ). The IPP offers an exciting, interdisciplinary and lively international community of more than 200 PhD students from over 40 different countries. You will receive a broad range of support including supervision, training and career development opportunities.
- Good experience in molecular biology
- Good communication skills and good team spirit
- Ability to solve problems independently
- Fluent in English (spoken and written)
- Competitive salary and favourable pension scheme
- Advanced training opportunities
- Flexible working hours
- Employee events
- Job Ticket
- Starting Date : as soon as possible
- Duration : the position is initially funded until 30 June 2028; with a possibility of extension
- Deadline : 31 August 2025
- International applicants: we will assist you through the visa process, and also with your application for a residence/work permit after your arrival in Mainz.
BTA - Molecular Biology (m/f/d)
Heute
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Symrise is a global supplier of fragrances and flavors, cosmetic active ingredients as well as functional ingredients. Its customers include perfume, cosmetics, food and beverage manufacturers, the pharmaceutical industry and producers of dietary supplements and pet food.
With sales of around €5.0 billion in the 2024 financial year, the company is one of the world's leading providers. The Group, headquartered in Holzminden, Germany, has more than 100 locations in Europe, Africa and the Middle East, Asia, the USA and Latin America.
Together with its customers, Symrise develops new ideas and market-ready concepts for products that form an indispensable part of everyday life. Economic success and corporate responsibility are inextricably linked.
Symrise - always inspiring more.
This is a 12-month fixed-term position .
As a Technologist you will expand our Biosystems Cell Factories team by driving the development of biotechnological processes through hands-on lab work. Key tasks of your role in our molecular and microbiological environment include:
- Execution and documentation of experiments in the biotechnological laboratories li>Construction of synthetic cell factories
- Cultivation trials and media optimization for S1 microorganisms
- Development and implementation of enzymatic assays
- Preparation and analysis of chromatographic samples
- Production of sensory samples
- General maintenance of the laboratories
- Completed vocational training as a biology laboratory technician with 2+ years experience or comparable technical background, e.g. Bachelor/Master of Science in biotechnology, molecular biology, microbiology or related fields
- Excellent knowledge in biotechnology with focus on molecular biology, microbial cultivation, biotransformation & enzyme assay development
- Confident handling of relevant research tools (e.g. PubMed, SciFinder, BLAST)
- Knowledge of natural product chemistry and basic analytical techniques would be beneficial
- Confident handling of the MS 365 suite
- You are an independent, proactive & collaborative team player, demonstrating attention to detail and upholding high standards
- Proficiency in written and spoken English is expected, Advanced German skills (minimum C1 level) are essential.
Become part of our open and transparent culture. It will give you the opportunity to flourish and to develop inspiring experiences that contribute to the health and well-being of consumers in 160 countries around the world. Putting our employees in the focus fuels our strong company growth above market rates and makes us an excellent place to develop your career.
Come join us and embark on a fascinating journey with Symrise.
If you feel that you fit the above criteria, then please apply by using our online application system. Your application will be treated confidentially.
PhD student - Molecular Biology (m/f/d)
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“Research for a life without cancer" is our mission at the German Cancer Research Center. We investigate how cancer develops, identify cancer risk factors and look for new cancer prevention strategies. We develop new methods with which tumors can be diagnosed more precisely and cancer patients can be treated more successfully. Every contribution counts - whether in research, administration or infrastructure. This is what makes our daily work so meaningful and exciting.
Together with university partners at seven renowned partner sites, the German Cancer Research Center (DKFZ) has established the German Cancer Consortium (DKTK).
For the DKTK partner site Munich , we are seeking for the next possible date a
PhD Student in Mutational Processes Driving Somatic EvolutionFrom cigarette smoke and UV radiation to chemotherapeutic cancer treatments, the cells in our bodies are constantly struck by exogenous agents that damage our DNA. The processes that evolved to repair and tolerate damage are responsible for many of the mutations that cause cancer and treatment resistance. But their dynamics, the molecular machinery involved, and their role in disease are still poorly understood. This is where you come in.
The newly established Cancer Systems Biology lab of Dr. Craig Anderson is searching for an enthusiastic PhD student to play a principal role in understanding how DNA damage leads to mutational heterogeneity across our bodies and over the course of our lives.
The lab is situated in the Department of Translational Oncology at the DKTK partner site at the LMU Klinikum, Munich. DKTK is a multi-location collaboration between DKFZ and leading university medical centres, so you stand to benefit from the combined opportunities that come from being part of some of Germany’s finest research institutes.
Munich itself is a beautiful and centrally located city, offering all the trappings of a modern lifestyle. It provides easy access to other cities and green spaces across the region, regularly scoring highly across indices for happiness and quality of life.
Relevant work:
Anderson CJ et al. Strand-resolved mutagenicity of DNA damage and repair. 2024. Nature 630: 744. doi.org/10 .1038/s41586-024-07490-1
Nicholson MD, Anderson CJ, et al. DNA lesion bypass and the stochastic dynamics of transcription coupled repair. 2024. PNAS 121: 20. doi.org/10 .1073/pnas.
Aitken SJ, Anderson CJ, et al. Pervasive lesion segregation shapes cancer genome evolution. 2020. Nature, 582: 7815. doi.org/10 .1038/s41586-020-2435-1
Get in touch to find out more, or apply today!
You will benefit from:
- Access to world-class training and mentorship li>Involvement in cutting-edge research
- Opportunities to contribute towards publication and peer review
- Dedicated funding for international conference attendance
- A supportive, flexible and collaborative working environment
Dr. Anderson has been a central figure in the discovery that DNA damage is heritable, and you’ll build on this work by using molecular methods to unravel the forces that modulate mutagenesis across the genome of mutagen-exposed cancer cells. You’ll be introduced to advanced statistical and computational methods for analysis of the data you create. Your findings will be a vital part of understanding the evolution of cancer drug resistance in cell models and in patients. < p>
- You’re extremely capable, using creativity and ingenuity to rise to new challenges.
- You’ve got an excellent M.Sc. degree in cancer genetics, molecular biology, or similar.
- You have laboratory experience and an interest in developing your bioinformatic skills.
- Y u have very good written and oral communication skills in English.
The position requires an excellent understanding of molecular biology, with demonstrable experience in the use of CRISPR in mouse or human cells. You must be capable of working independently to confidently manage your own day-to-day research across laboratory experiments and bioinformatic analyses concurrently. You should be able to show evidence of working collaboratively, with respect for diversity among your colleagues and the institutional positions held. The working language in the lab is English, and you must have an outstanding ability to communicate with your colleagues in the department. You also need to communicate your research clearly through publication, in meetings, with collaborators, and in presentations at national and international conferences. You should see the value in working safely and in maintaining accurate records. Above all, you need to have a can-do attitude driving you to learn, adapt and succeed.
Desirable skills or willingness to learn to include:
Toxicant exposure; experience in short- and long-read sequencing; computational and statistical analyses; a good mechanistic understanding of how cells replicate their DNA and respond to DNA damage.
- Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level
- Access to international research networks
- Doctoral salary with the usual social benefits
- 30 days of vacation per year
- Flexible working hours
- Possibility of part-time work
- Family-friendly working environment
- Sustainable travel to work: subsidized Germany job ticket
- Unleash your full potential: targeted training and mentoring through the DKFZ International PhD Program and DKFZ Career Service
- Our Corporate Health Management Program offers a holistic approach to your well-being
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Senior Research Scientist - Molecular Biology (m/w/d)
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PhD Student Biology, Molecular Biology (m/f/d)
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GEOMAR Helmholtz Centre for Ocean Research Kiel is a foundation under public law jointly financed by the Federal Republic of Germany (90%) and the State of Schleswig-Holstein (10%). It is one of the internationally leading institutions in the field of marine research.
Through our research and our commitment to the transfer of knowledge and technology, we contribute significantly to the preservation of the function and protection of the ocean for future generations.
The research unit ‘Experimental Ecology’ investigates how coastal ecosystems respond to climate change. We are particularly interested in how benthic foundation species such as macroalgae, corals and bivalves cope with summer heat wave mortality and whether heat tolerant genotypes that currently exist at low frequencies are selected by intense heat waves. Ultimately, we want to use information on adaptive potential in models to better predict geographic range shifts of important foundation species and their associated communities under various climate change scenarios. We utilize unique outdoor mesocosm systems (Kiel Outdoor Benthocosms, KOBs) to experimentally select from thousands to millions of genotypes within complex communities and couple these experiments with field studies.
An important model species in our research unit is the macroalga Fucus vesiculosus. F. vesiculosus forms extensive meadows in temperate coastal habitats and has a very limited dispersal potential, leading to potentially strong genetic differentiation along coastlines. We have recently succeeded in mass-fertilization of hundreds of genotypes and rearing of juvenile algae in mesocosms under different thermal scenarios. We now want to study selection dynamics in such experiments to identify genomic targets of selection and to phenotype heat-resistant survivors. The research unit Experimental Ecology of the research division Marine Ecology is offering the following position starting on October 1st 2025. The position offers the possibility to attain a doctoral degree in natural sciences.
Project Description
The candidate is going to be part of the collaborative project FUBLUC (ca. 20 participants) that aims to (i) understand the blue carbon potential of Fucus meadows in the Baltic Sea and (ii) to develop methods to restore Fucus algal meadows in degraded habitats. For the latter, a detailed understanding of local adaptation of Fucus populations living in thermally variable habitats along the German Baltic Sea coast is necessary. We aim to explore Fucus productivity and associated biodiversity in relation to thermal variability at several locations. From these populations, we will breed specimen in the lab and mesocosms to study heat stress responses, heritability of heat-related traits and the genomic basis for heat tolerance. In addition, we want to develop techniques to restore Fucus-depleted habitats using genetically diverse breeding stocks to select for genotypes that have superior fitness in specific habitats.
Position:
The successful candidate will (i) describe physiological characteristics of thermal tolerance of Fucus juveniles between populations in mesocosm and laboratory experiments, (ii) identify genomic loci linked to thermal tolerance, and (iii) perform trials to monitor resilience of selected lineages of F. vesiculosus in the southwestern Baltic Sea in field experiments.
- Master degree in Biology, Molecular Biology, Genomics or related fields of study li>Experience with state-of-the art molecular biological lab techniques (e.g. nucleic acid extraction, sequencing library preparation, Hi-C, ATAC-seq etc.)
- Experience with bioinformatic analysis of large sequencing data sets
- Strong statistical skills using R
Desirable:
- Experience with assembly, annotation and/or analysis of plant or algal genomes
- Expertise in evolutionary biology and evolutionary genomics
- Experience with algal or plant ecophysiological approaches
- Experience with nanopore sequencing
At a workplace, directly on the Kiel Fjord with many leisure and recreational opportunities, we offer you:
- Work in the field of marine and climate research, a forward-looking area with social significance
- An exciting and international work environment with the opportunity to provide important impetus for the development of sustainable solutions
- Support services for professional and personal life situations
- Good conditions for work-life balance: We offer, among other things, the possibility of mobile working and individual working time arrangements, vacation courses for the children of our employees, and good support in finding a place in a daycare center at the Kiel site
- International work environment
- 30 vacation days + additional time off at Christmas Eve and on New Year's Eve
- Company pension plan and capital-forming benefits
The position is available for a funding period of 3.5 years. The envisioned start is October 2025. The salary depends on qualification and could be up to the class E13 (TVöD-Bund) of the German tariff for public employees.
This is a part-time position according to 75% of a full-time equivalent. The position cannot be split. Flexible work-time models are possible.
GEOMAR Helmholtz Centre for Ocean Research Kiel seeks to increase the proportion of female scientists and explicitly encourages qualified female academics to apply. GEOMAR is an equal opportunity employer and encourages scientists with disabilities to apply. Qualified disabled applicants will receive preference in the application process.
PhD Student Molecular Biology, Cell Biology (m/f/d)
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Project "Control of Endoplasmic Reticulum and Lipid Droplet biogenesis by the Lipin switch"
Eukaryotic cells are amazing architects. They build elaborate membrane-bound organelles and radically remodel them when they differentiate or adapt to stress. As a result, the same organelle can have very different sizes and shapes in different cells and can carry out specialised functions.
Our lab at the Biochemistry Center of Heidelberg University investigates the molecular mechanisms by which cells respond to changing demand for endoplasmic reticulum (ER) function. These mechanisms include activation of the unfolded protein response, induction of lipid synthesis to drive ER membrane biogenesis, selective autophagy of the ER and regulation of morphogenic proteins to shape the ER. To find out more about our research and us, please visit our website at .
The advertised project offers the opportunity to explore the role of the conserved lipid phosphatase Lipin in lipid metabolism and organelle size control. Lipin catalyses the conversion of phosphatidic acid into diacylglycerol and thus provides precursors for membrane and storage lipids. In addition, Lipin regulates the transcription of lipid metabolism genes. These activities of Lipin are important for the biogenesis of the ER membrane and lipid droplets. Lipin activity depends on its switch-like relocation from the cytosol to the ER and the nucleus.
Building on our previous work in yeast (Papagiannidis et al., EMBO Journal, 2021), we want to determine how human cells use the Lipin switch to coordinate ER and lipid droplet biogenesis with current metabolic needs. In addition, we aim to develop Lipin inhibitors to manipulate Lipin activity, potentially to tackle disorders such as obesity and fatty liver disease.
The project will be carried out in collaboration with the laboratory of Oliver Daumke at the Max Delbrück Center for Molecular Medicine in Berlin and is part of the research network Molecular Switches ( ). It will involve a variety of biochemical and cell biological techniques, including extensive light microscopy of human tissue culture cells, automated image analysis to quantify ER and lipid droplet abundance and morphology, genome editing and transcriptional analyses.
If you are passionate about basic science, eager to push your own project forward and ready to support others, our lab may be the right place for you. A strong background in biochemistry and molecular cell biology is essential; previous experience with mammalian tissue culture and microscopy is helpful but not a must.